A simple tutorial on installing NONMEM on a Mac

*As of December 17th 2023, the following configurations have been verified.

*Update: NONMEM 7.5.1 will address the installation issue on Mac with Apple silicon

*NONMEM 7.5.0 and earlier versions can not be successfully configured on macOS version Monterey or greater due to the change in command line tools. If you have a Mac running Monterey, you need to downgrade your macOS version to Big Sur or earlier versions

MacOS configuration Link to heading

1. Open the terminal and enter: xcode-select --install

NONMEM Download Link to heading

1. Install fortran compiler (gfortran)

   • Run …/NM743CD/compilers/gfortran-macosx-x86.dmg
   • (Alternatively, you can download other GFortran versions here.)
   • To validate installation, open the terminal and enter gfortran -c

2. Install NONMEM

   • Open the terminal and go to the root directory of NONMEM installation source and enter:

     sudo /bin/bash path_to_nonmem_source/SETUP74 /your_target_path gfortran
     

     For example:

     sudo /bin/bash ./SETUP74 /opt/nm74 gfortran
     

   • Then wait (for long)

PsN (optional) Link to heading

1. Install Perl

   • Check if perl exists by running perl -v
   • If not, download it here: https://www.activestate.com/products/activeperl/downloads

2. Install Perl packages.

   sudo cpan Math::Random
   sudo cpan Moose
   sudo cpan MooseX::Params::Validate
   sudo cpan Statistics::Distributions
   sudo cpan Archive::Zip
   sudo cpan File::Copy::Recursive
   sudo cpan YAML::XS
   sudo cpan Storable
   

   Other packages may be needed, should be figured out in the next step.

3. Install PsN

   • Open the terminal and navigate to the root directory of PsN installation source and enter

     sudo perl setup.pl
     

   • PsN will check/ask you several things:

     • Where is your perl installed? Find the answer by entering which perl
     • Where do you want PsN utilities installed? /opt/PsN/bin/
     • Where do you want PsN source code copied to? /opt/PsN/
     • Where do you want documents copied to? /opt/PsN/ and install packages (check step 2 for how)

   • Write to environment variable:

     echo 'EXPORT PATH=~/PsN/bin:$PATH' >> ~/.bash_profile
     

     or

     cp /etc/paths /etc/paths_backup
     
     echo '/opt/PsN/bin' >> /etc/paths
     

   • Test PsN installation: which psn